Science & Publications about Stem Cells / Life Science industry

Over 250 studies of animal stem cell treatments have been published in the peer-reviewed scientific and professional medical literature. The following articles and reviews provide scientific study and clinical application references.

Intra-articular Administration of Allogeneic Adipose-Derived MSCs Reduces Pain and Lameness in Dogs With Hip Osteoarthritis: A Double-Blinded, Randomized, Placebo-Controlled Pilot Study (2020)

By Chad B. Maki1, Anthony Beck, Chan-Benami Cheuk Chi Wallis, Justin Choo, Thomas Ramos1, Raymond Tong, Dori L. Borjesson5 and Fariborz Izadyar

This study was conducted to investigate the therapeutic effect of allogeneic adipose-derived MSCs on dogs with hip osteoarthritis (OA). Twenty dogs with bilateral osteoarthritis of the coxofemoral (hip) joint, diagnosed by a veterinarian through physical examination and radiographs were randomly allocated into four groups.

See the full article here.

STEM CELL THERAPY FOR TENDON REGENERATION: CURRENT STATUS AND FUTURE DIRECTIONS (2018)

By Sabine Conrad, Kathrin Weber, Ulrich Walliser, Florian Geburek, and Thomas Skutella

About chapter: In adults, the healing tendon generates fibrovascular scar tissue and recovers never histologically, mechanically, and functionally which leads to chronic and to degenerative diseases. In this review, the processes and mechanisms of tendon development and fetal regeneration in comparison to adult defect repair and degeneration are discussed in relation to regenerative therapeutic options.

We focused on the application of stem cells, growth factors, transcription factors, and gene therapy in tendon injury therapies in order to intervene the scarring process and to induce functional regeneration of the lesioned tissue.

Outlines for future therapeutic approaches for tendon injuries will be provided.

Please contact us to have access to this review.

Book chapter: Stem Cell Therapy for Musculoskeletal Diseases (2019)

Book chapter by Benjamin B. Rothrauff, Alessandro Pirosa, Hang Lin, Jihee Sohn, Mark T. Langhans, Rocky S. Tuan
University of Pittsburgh School of Medicine, Pittsburgh, PA, United States

About chapter: This review focuses on stem cell therapies for musculoskeletal diseases. In particular, we highlight stem cell applications for individual tissues of the musculoskeletal system (bone, articular cartilage, tendon and ligament, meniscus, intervertebral disc, and skeletal muscle) as well as transitions between tissues (osteochondral interfaces and tendon-bone interfaces). For each, the relevant structure and function are described. Because embryological development of these tissues and the phenotypic characteristics of their resident cells are described in detail in other chapters, only a succinct discussion of tissue-specific endogenous cells is included. There is an emphasis on findings of preclinical and clinical studies when possible.

Please contact us to have access to this book chapter.

Evaluation of the Effect of a Single Intra-articular Injection of Allogeneic Neonatal Mesenchymal Stromal Cells Compared to Oral Non-Steroidal Anti-inflammatory Treatment on the Postoperative Musculoskeletal Status and Gait of Dogs over a 6-Month Period after Tibial Plateau Leveling Osteotomy: A Pilot Study

Front. Vet. Sci., 08 June 2017
//www.medrego.com/publications/Canine-2017.pdf

BLINDED PLACEBO STUDY OF BILATERAL OSTEOARTHRITIS TREATMENT USING ADIPOSE DERIVED MESENCHYMAL STEM CELLS

Slovenian Veterinary research
March 2016
http://www.slovetres.si/index.php/SVR/article/view/204

Assessment of regeneration in meniscal lesions by use of mesenchymal stem cells derived from equine bone marrow and adipose tissue

American Journal of Veterinary Research
July 2016, Volume 77, Pages 779-788
http://avmajournals.avma.org/doi/10.2460/ajvr.77.7.779

Mesenchymal Stem Cell Therapy (book chapter)

Equine Clinical Immunology
5 January 2016, Pages 297-310
http://onlinelibrary.wiley.com/doi/10.1002/9781119086512.ch31/summary;jsessionid=7CAE2D6BD8BCDBD69AE42626A3727E77.f02t03

Stem cell therapy status in veterinary medicine (review)

Tissue Engineering and Regenerative Medicine
August 2015, Volume 12, pp 67–77
https://link.springer.com/article/10.1007%2Fs13770-014- 0426-8

Mesenchymal stem cell therapy in horses: Useful beyond orthopedic injuries? (review)

Veterinary Quarterly
December 2013, Volume 33, Pages 234-241
http://www.tandfonline.com/doi/abs/10.1080/01652176.2013.800250

Mesenchymal stromal cell cryopreservation

Biopreservation and Biobanking
June 2012, Volume 10, Pages 276-281
http://online.liebertpub.com/doi/abs/10.1089/bio.2012.0005